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Executive functions include 'thinking outside the box' (cognitive flexibility), mentally relating ideas and facts (working memory), and giving considered responses rather than impulsive ones, resisting temptations and staying focused (inhibitory control, including selective attention). She has made discoveries that have improved treatment for two different medical disorders and discoveries that have impacted education, improving the lives of millions of children. Her work has shown that executive functions can be improved even in the very young. Adele Diamond was educated at Swarthmore (B. A., Phi Beta Kappa), Harvard (Ph. D.), and Yale Medical School (postdoc). Her many awards include an honorary doctorate (Honoris Causa) from Ben- Gurion University, the Bronfenbrenner Award for Lifetime Contributions to Developmental Psychology in the Service of Science and Society, named a . EFs include being able to 'think outside the box' and see things from other perspectives (cognitive flexibility), mentally relating different ideas and facts to one another (working memory), and giving a considered response rather than an impulsive one, resisting temptations, and staying focused (inhibitory control, including selective attention). These abilities are crucial for problem- solving, creativity, and reasoning, and for success in all life's aspects. One goal of the lab is to examine fundamental questions about how PFC and EFs are influenced by biological factors (such as genes and neurochemistry) and by environmental factors (including detrimental influences such as poverty or stress and facilitative ones such as interventions). For example, the lab examines ways in which unusual properties of the PFC dopamine system contribute to the exceptional sensitivity and vulnerability of PFC and EFs to environmental and genetic variations that have little effect elsewhere in the brain, and how at least some of these effects are different in men and women. One unusual aspect of the DA system in PFC is a relative dearth of DA transporter proteins, the best way for clearing away released DA. This has many interesting and practical consequences. One of those relates to attention- deficit hyperactivity disorder (ADHD). We predict, and are testing, that physicians prescribing the correct dose of psychostimulants for controlling hyperactivity in patients with ADHD are prescribing too high a dose for patients. Physicians decide on the optimal psychostimulant dose for a child with ADHD by asking the child. The parent bases his/her answer on the child. No one tests the child. We offer a markedly different perspective from mainstream education in hypothesizing that focusing exclusively on training cognitive skills is less efficient, and ultimately less successful, than also addressing youths. Our hypothesis is that besides training the skill(s) of interest, it. Researchers and educators tend to focus on one aspect of a person in isolation. For example, efforts to study or to improve cognitive skills (such as EFs) or academic performance are generally done ignoring whether participants are happy or sad, lonely or healthy. Yet sadness, stress, loneliness, or poor health causes one. Conversely, EFs are better when one feels emotionally and socially nourished and healthy. Social and/or emotional aspects of, or adjuncts to, a program to improve cognitive skills might be key to whether and/or how much that program succeeds. We hope our research might fundamentally change the approach and underlying assumptions (i. We expect to show that focusing exclusively on training cognition might not be the best way to improve cognition; emotional and social factors might be key to whether cognition improves. Traditional activities that have been part of all cultures throughout time (e. EFs (requiring focus, concentration, and working memory), make us happy and proud, provide a sense of belonging, and help our bodies develop. Recently we have turned our attention to the possible roles of music, dance, storytelling, traditional martial arts, positive sports, yoga, mindfulness, and even circus for improving executive functions, academic outcomes and mental and physical health. In the 1. 98. 0s,Adele Diamond. As a graduate student, Diamond realized that for 5. Developmental psychologists called it . Diamond & Goldman- Rakic, 1. Diamond & Goldman- Rakic, 1. This established the first strong link between early cognitive development and the functions of a specific brain region. That gave encouragement to others that rigorous experimental work addressing brain- behavior relations was possible in infants. It also fundamentally altered the scientific understanding of PFC early in development; clearly it was not silent as accepted wisdom had held. Even though PFC is very immature early in life and takes a very long time to develop, it can already subserve elementary versions of the highest cognitive functions during the first year of life. Diamond went on to facilitate many of the earliest collaborations between developmental and cognitive scientists, on the one hand, and neuroscientists on the other. In the 1. 99. 0s, Diamond. Diamond identified the biological mechanism causing EF deficits in children treated for PKU. No one had ever done anything like that. Again, the answer lay in integrating two fields. Researchers and clinicians working on inborn errors of metabolism had noticed that children . Neuropharmacologists studying the mesocortical dopamine system in rats had shown that if there is only a modest reduction in the dopamine precursor, tyrosine, PFC is selectively affected. Since Phe and tyrosine compete to enter the brain, a modest elevation in the Phe to tyrosine ratio in blood would result in a modest reduction in the amount of tyrosine reaching the brain . They were thereby able to demonstrate the mechanism causing the deficits that had so confounded those working in inborn errors of metabolism, and to demonstrate that the deficits could be prevented by stricter dietary restrictons. Midway through, Diamond learned that the dopamine system in the retina shares the same unusual properties as those that cause PFC to be sensitive to reductions in available tyrosine too small to affect other brain regions. To be consistent, she had to predict that retinal function would also be adversely impacted in children treated for PKU, so she ventured into vision science to investigate that together with pediatric optometrist, Dr. Sure enough, her team identified the first visual deficit reported in children treated for PKU . Impaired sensitivity to visual contrast in children treated early and continuously for PKU. Brain, 1. 19, 5. 23- 5. Diamond, A., Prevor, M., Callender, G., & Druin, D. P. Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. Monographs of the Society for Research in Child Development (Monograph #2. Zagreda, L., Goodman, J., Druin, D. P., Mc. Donald, D., & Diamond, A. Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation. Journal of Neuroscience, 1. Diamond, A. A model system for studying the role of dopamine in prefrontal cortex during early development in humans. Luciana (Eds.), Handbook of developmental cognitive neuroscience (p. Cambridge, MA: MIT Press. Blackwell Press. Diamond. By the time her team studied contrast sensitivity, they knew what range of Phe levels produced a deficit and so only sampled from within that range. The children whose brains were exposed to massive levels of Phe for the first 1. On the basis of this presentation, US national guidelines for when dietary treatment for PKU should begin changed from by 1. Recent research findings on the effects of age at diet initiation on the visual system. Invited presentation at the NIH Consensus Development Conference on . Consequences of variations in genes that affect dopamine in prefrontal cortex. Cerebral Cortex, 1. Scientific results are rarely perfectly neat and clean. Why on earth were they not impaired on these 3 tasks? But again she was unwilling to let the inconsistency remain uninvestigated. Those investigations uncovered that while self- ordered pointing depends on PFC, it is not sensitive to the level of DA in PFC and hence is not affected in children with PKU. Those investigations also led to a line of research, adding techniques in molecular genetics to her arsenal, leading to: 3. In the 2. 00. 0s, Diamond. The best way to clear released DA is with the dopamine transporter protein. PFC is unusual in that it has very little dopamine transporter. Unlike other brain regions, PFC has to rely on the catechol- o- methyltransferase (COMT) enzyme to clear DA. For persons of European origin, they are as likely to have a version of the COMT gene that codes for a fast- acting COMT enzyme, leaving less DA in PFC (i. Their results challenged accepted notions that since DA is important for some PFC- dependent cognitive functions, it is important for all (since as predicted, COMT genotype was unrelated to self- ordered pointing performance). The differential sensitivity of distinct cognitive abilities to specific neurotransmitters opens up possibilities for targeted pharmacological interventions. Diamond. Estrogen down- regulates COMT gene transcription; the COMT enzyme is 3. COMT enzyme clears DA more slowly, leaving more DA around longer in PFC). Diamond and her team hypothesized that women may have higher baseline levels of DA in PFC (a more optimum level) and males. That would be consistent with disorders of too little DA in PFC (e. ADHD) being more common in males and disorders of too much DA in PFC (e.
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If you have Blaise Kindle give Alma Drill a hug, she will often get a wish to kiss her. Their household description also says: . Aurora Skies gives us Jesper Sandstrom and Viktor Valquist, who seem a lot like a gay couple raising an adopted child together (the one who officially adopted her even gives her a invoked. Portmanteau Surname) but are presented in- game as best friends. Anachronism Stew: The Sims 3 contains anachronisms within its own universe. The game is set 2. There are many interpretations to the internet for this web marketing or similar terms such as: online marketing, internet marketing, e-marketing and others. Edotek is a scientific consultancy which provides technical assistance to industry and other agencies helping them to solve problems in the areas of chemistry and. Call of Duty: Modern Warfare Remastered Campaign Launch Trailer; Mafia 3 Gameplay Demo; Destiny: Rise of Iron How To Get Exotic Weapons Guide; Call of Duty. Sims game, making Bella Goth a child, but your Sims can go down to the library and read books titled Where's Bella and A Pleasantview Murder by Alexander Goth. There are no aliens in the base game of TS3, yet in TS2 there are premade sisters in the same town with an alien ancestor. And then there's Don Lothario's time machine.. The Sims 2 did mention that the Caliente sisters moved into town after Bella disappeared. The Tragic Clown is a ghost in TS3, yet can be encountered alive in the original Sims. The introduction of laptops when they are canonically absent in TS1 and TS2. Egyptian mummies in China and France. Slightly justified for France, given that Napoleon ordered the archeologic explorations of Egyptian ruins. For China, not so much. The store sets can lead to this as while the game is primarily modern, historical or futuristic content can be bought and used. And Your Reward Is Clothes: In addition to all the perks that come with your career (money), you'll also unlock any and all career uniforms, like astronaut suits. Animorphism: Pets allows you to use karma to turn a person into a dog or cat. Artificial Stupidity: While this is greatly reduced from the first game (definitely less Sims peeing themselves for no apparent reason), there still are some elements of this: Give a home with two adults and a child only one bed, and anyone left without a bed will complain at those using them. There is no check for the appropriateness of doing so, so the husband may find his wife and daughter sleeping in the only double bed, and order the wife out of it. Sims also will leave babies outside instead of in a crib occasionally. When switching households, you may find that due to story progression, the entire family will be at the beach at 1. AM on a Tuesday, children and all, despite needing to be at school/work. This sometimes causes sims to be fired from their job. In nightclubs with elevators (a common feature in Bridgeport), if there's only one elevator, all the Sims present will try to crowd into it, jamming the whole thing up. A not- uncommon sight is finding a large gathering of Sims just standing around in front of an elevator come closing time. Artistic License . Potatoes, carrots and onions are root vegetables. Bananas do not grow on trees. And so on, and so forth. Pets: Calico cats are listed as a breed, even though in real life . You can create fertile male calicoes, even though calico coloured cats in real life are always female, as the calico coloration is caused by one of her X chromosomes possessing a gene for orange fur, with her second X lacking an orange gene (both X's would have to have an orange gene for her to be fully orange, hence why orange cats are usually male). An extremely rare exception to this rule can occur if a male inherits an extra X chromosome from a glitched sperm cell; in which case, he will almost always be sterile. Artistic License . While modelling accurate driving physics and behavior is perhaps beyond the scope of this game, They Just Didn't Care enough to even try to hide the fakery. To build a second floor for your house, you have to provide support for it by way of pillars. Once the second floor has been built however, you can do as you please with them. Yes, you can even delete them. A few prebuilt houses even use this intentionally. Awesome, but Impractical: Ambrosia, which when eaten increases lifespan by a huge amount, gives the second best moodlet in the game, and turns playable Ghost Sims into regular Sims - but it requires a Life Fruit (rare, requires Gardening skill of at least seven), a Death Fish (easy to find, hard to catch, requires a very high fishing skill or suitable bait, which requires suitable bait, which requires suitable bait, though the starting bait in the series is easy to get) and a Cooking skill of ten, plus the recipe costs 1. Simoleons! With some work, though, you can guarantee yourself a steady supply of the ingredients. The Philosopher's Stone lifetime reward can convert items into gold bars for profit. The problem is that not only is it very expensive (costs you 4. Not only that but the Philosopher's Stone has a rather high chance of failing and can end up either deleting your item, or turning your Sim into a gold statue and killing them in the process. Though your Sim may not even have to die at all if they have the Unlucky or Loser traits, or have a Death Flower in their inventory. When paired with a rare plant called a Death Flower, using the Philosopher's Stone averts this and can be a big money maker, doubly so if University Life is installed and a Scientist can clone it. The Philosopher's Stone also allows you to bind ghosts as a slaves. Ghosts can use the Philospher Stone's transmute abilty. Possibly the so- called . If you wanted to take this trope literally, you could change pretty much every object, wallpaper and floor covering into bamboo.. With World Adventures, if your Sim is a writer, you can get an opportunity saying that your books have, literally, been banned in China. Baths Are Fun: Taking a bath as opposed to a shower can help a stressed out Sim to relax, Even more so if there's a rubber duckie in the bathtub. Bath of Poverty: The cheapest shower will sometimes lose heat partway through use, resulting in a . It also causes your Sim to emit a red glow that causes their relationship with all nearby Sims to steadily plummet. This causes the Emperor to slowly lose all their friends, especially if they're in the Emperor's household and therefore near him or her a lot of the time. Bewitched Amphibians: (Supernatural): Witches can learn a curse that turns other Sims into toads (but just their heads; they still walk around like normal Sims, though). Also in Supernatural,Fairies can trick people into vomiting frogs, and gold, making this a literal mixed blessing. Big Ball of Violence: With Pets, a cat will get into one of these when it goes hunting. If it has low skill levels, it's probably going up against an insect.. Along with dogs they can also fight raccoons like this. Sims do this while fighting, with bar fights creating huge ones that any Sim can join and jump into. Big Screwed- Up Family: The Racket family from Twinbrook is a good example, seeing as they were likely based on a family version of the Mafia. The Shallows in Riverview are this as well, all having Evil traits and (according to the backstory, at least) not getting along with each other very well. Birds of a Feather: Sims who share traits with another would get along with each other much better (e. Nice sims would befriend fellow nice sims more quickly, bookworms with fellow bookworms, etc.). The only exception is the . Freak Out CANNOT be cancelled out of, and interrupts anything you are trying to do. Body Horror: If you're feeling daring, look at the nightmare fuel image pic. This glitch is freaky as hell. |
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December 2016
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